The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma

Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is a valid therapeutic approach against melanoma. We targeted NOTCH signaling using RO4929097, a novel inhibitor of gamma secretase, which is a...

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Detalhes bibliográficos
Main Authors: Huynh, Chanh, Poliseno, Laura, Segura, Miguel F., Medicherla, Ratna, Haimovic, Adele, Menendez, Silvia, Shang, Shulian, Pavlick, Anna, Shao, Yongzhao, Darvishian, Farbod, Boylan, John F., Osman, Iman, Hernando, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182998/
https://ncbi.nlm.nih.gov/pubmed/21980408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025264
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