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Exhausted CD8 T Cells Downregulate the IL-18 Receptor and Become Unresponsive to Inflammatory Cytokines and Bacterial Co-infections

During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they lose their ability to respond to antigenic activation. Combinations of IL-12, IL-18, and IL-21 have been shown to induce the antigen-independent production of interferon (IFN)-γ by effector and memory CD8 T cells...

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Detalhes bibliográficos
Main Authors: Ingram, Jennifer T., Yi, John S., Zajac, Allan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182940/
https://ncbi.nlm.nih.gov/pubmed/21980291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002273
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