Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

Human wild-type superoxide dismutase-1 (wtSOD1) is known to coaggregate with mutant SOD1 in familial amyotrophic lateral sclerosis (FALS), in double transgenic models of FALS, and in cell culture systems, but the structural determinants of this process are unclear. Here we molecularly dissect the ef...

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Autori principali: Grad, Leslie I., Guest, Will C., Yanai, Anat, Pokrishevsky, Edward, O'Neill, Megan A., Gibbs, Ebrima, Semenchenko, Valentyna, Yousefi, Masoud, Wishart, David S., Plotkin, Steven S., Cashman, Neil R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182705/
https://ncbi.nlm.nih.gov/pubmed/21930926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102645108
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