GSTP1 DNA Methylation and Expression Status Is Indicative of 5-aza-2′-Deoxycytidine Efficacy in Human Prostate Cancer Cells

DNA methylation plays an important role in carcinogenesis and the reversibility of this epigenetic modification makes it a potential therapeutic target. To date, DNA methyltransferase inhibitors (DNMTi) have not demonstrated clinical efficacy in prostate cancer, with one of the major obstacles being...

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Autores principales: Chiam, Karen, Centenera, Margaret M., Butler, Lisa M., Tilley, Wayne D., Bianco-Miotto, Tina
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182253/
https://ncbi.nlm.nih.gov/pubmed/21980513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025634
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