KAP Degradation by Calpain Is Associated with CK2 Phosphorylation and Provides a Novel Mechanism for Cyclosporine A-Induced Proximal Tubule Injury

The use of cyclosporine A (CsA) is limited by its severe nephrotoxicity that includes reversible vasoconstrictor effects and proximal tubule cell injury, the latter associated whith chronic kidney disease progression. The mechanisms of CsA-induced tubular injury, mainly on the S3 segment, have not b...

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Bibliographic Details
Main Authors: Tornavaca, Olga, Sarró, Eduard, Pascual, Gloria, Bardaji, Beatriz, Montero, M. Angeles, Salcedo, M. Teresa, Plana, Maria, López-Hellin, Joan, Itarte, Emilio, Meseguer, Anna
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182248/
https://ncbi.nlm.nih.gov/pubmed/21980535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025746
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