First Phase 1 Double-Blind, Placebo-Controlled, Randomized Rectal Microbicide Trial Using UC781 Gel with a Novel Index of Ex Vivo Efficacy

OBJECTIVES: Successful control of the HIV/AIDS pandemic requires reduction of HIV-1 transmission at sexually-exposed mucosae. No prevention studies of the higher-risk rectal compartment exist. We report the first-in-field Phase 1 trial of a rectally-applied, vaginally-formulated microbicide gel with...

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Bibliografiske detaljer
Main Authors: Anton, Peter A., Saunders, Terry, Elliott, Julie, Khanukhova, Elena, Dennis, Robert, Adler, Amy, Cortina, Galen, Tanner, Karen, Boscardin, John, Cumberland, William G., Zhou, Ying, Ventuneac, Ana, Carballo-Diéguez, Alex, Rabe, Lorna, McCormick, Timothy, Gabelnick, Henry, Mauck, Christine, McGowan, Ian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182160/
https://ncbi.nlm.nih.gov/pubmed/21969851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023243
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