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Host type I IFN signals are required for antitumor CD8(+) T cell responses through CD8α(+) dendritic cells

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently in response to a growing tumor. However, the innate immune mechanisms that promote natural antitumor T cell responses are undefined. In human metastatic melanoma, there was a correlation between a type I inter...

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Bibliografske podrobnosti
Main Authors: Fuertes, Mercedes B., Kacha, Aalok K., Kline, Justin, Woo, Seng-Ryong, Kranz, David M., Murphy, Kenneth M., Gajewski, Thomas F.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182064/
https://ncbi.nlm.nih.gov/pubmed/21930765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101159
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