Aquaporin-1 Promotes Angiogenesis, Fibrosis, and Portal Hypertension Through Mechanisms Dependent on Osmotically Sensitive MicroRNAs

Changes in hepatic vasculature accompany fibrogenesis, and targeting angiogenic molecules often attenuates fibrosis in animals. Aquaporin-1 (AQP1) is a water channel, overexpressed in cirrhosis, that promotes angiogenesis by enhancing endothelial invasion. The effect of AQP1 on fibrogenesis in vivo...

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Главные авторы: Huebert, Robert C., Jagavelu, Kumaravelu, Hendrickson, Helen I., Vasdev, Meher M., Arab, Juan P., Splinter, Patrick L., Trussoni, Christy E., LaRusso, Nicholas F., Shah, Vijay H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2011
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181328/
https://ncbi.nlm.nih.gov/pubmed/21854740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.045
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