Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB

The essential Mycobacterium tuberculosis Ser/Thr protein kinase (STPK), PknB, plays a key role in regulating growth and division, but the structural basis of activation has not been defined. Here we provide biochemical and structural evidence that dimerization through the kinase-domain (KD) N-lobe a...

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Detalhes bibliográficos
Main Authors: Lombana, T. Noelle, Echols, Nathaniel, Good, Matthew C., Thomsen, Nathan D., Ng, Ho-Leung, Greenstein, Andrew E., Falick, Arnold M., King, David S., Alber, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181147/
https://ncbi.nlm.nih.gov/pubmed/21134645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.09.019
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