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Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase
Many Ser/Thr protein kinases are activated by autophosphorylation, but the mechanism of this process has not been defined. We determined the crystal structure of a mutant of the Ser/Thr kinase domain (KD) of the mycobacterial sensor kinase PknB in complex with an ATP competitive inhibitor and discov...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2599879/ https://ncbi.nlm.nih.gov/pubmed/19008858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.236 |
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