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Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase

Many Ser/Thr protein kinases are activated by autophosphorylation, but the mechanism of this process has not been defined. We determined the crystal structure of a mutant of the Ser/Thr kinase domain (KD) of the mycobacterial sensor kinase PknB in complex with an ATP competitive inhibitor and discov...

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Hlavní autoři: Mieczkowski, Carl, Iavarone, Anthony T, Alber, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599879/
https://ncbi.nlm.nih.gov/pubmed/19008858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.236
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