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Identification of a Novel Selective Serotonin Reuptake Inhibitor by Coupling Monoamine Transporter-Based Virtual Screening and Rational Molecular Hybridization
[Image: see text] Ligand virtual screening (VS) using the vestibular binding pocket of a three-dimensional (3-D) monoamine transporter (MAT) computational model followed by in vitro pharmacology led to the identification of a human serotonin transporter (hSERT) inhibitor with modest affinity (hSERT...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2011
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3181111/ https://ncbi.nlm.nih.gov/pubmed/21966587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200044x |
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