Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon

BACKGROUND: The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen. METHODS: To clarify this immune response phenomenon, we evaluat...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Daquan, Liu, Wanhui, Shen, Yan, Mu, Hongjie, Zhang, Yanchun, Liang, Rongcai, Wang, Aiping, Sun, Kaoxiang, Fu, Fenghua
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2011
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181064/
https://ncbi.nlm.nih.gov/pubmed/21976980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S24344
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items