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Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells

The cumulative exposure to estrogens is an important determinant in the risk of breast cancer, yet the full range of mechanisms involving estrogens in the genesis and progression of breast cancer remains a subject of debate. Interactions of estrogens and environmental toxicants have received attenti...

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Detalhes bibliográficos
Main Authors: Spink, Barbara C., Bennett, James A., Pentecost, Brian T., Lostritto, Nicole, Englert, Neal A., Benn, Geoffrey K., Goodenough, Angela K., Turesky, Robert J., Spink, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180932/
https://ncbi.nlm.nih.gov/pubmed/19619570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.07.013
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