Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

BACKGROUND: Recent genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNP)s that are essentially unequivocally associated with peripheral cholesterol. Since the alleles of the APOE gene, which modulate peripheral cholesterol metabolism, and midlife plasma cholest...

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Main Authors: Simmons, Christopher R, Zou, Fanggeng, Younkin, Steven G, Estus, Steven
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180274/
https://ncbi.nlm.nih.gov/pubmed/21867541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-62
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