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A Convergent Synthesis of the Proposed Structure of Antitumor Depsipeptide, Stereocalpin A

[Image: see text] The total synthesis of the proposed structure of anticancer agent, stereocalpin A is described. The synthesis features a diastereoselective synthesis of a 5-hydroxy-2,4-dimethyl-3-oxo-octanoic acid unit with asymmetric anti- and syn-aldol reactions as the key steps. Initial cycloam...

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Bibliographic Details
Main Authors: Ghosh, Arun K., Xu, Chun-Xiao
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179852/
https://ncbi.nlm.nih.gov/pubmed/19354233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900412u
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