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Mitochondrial Respiration Inhibitors Suppress Protein Translation and Hypoxic Signaling via the Hyperphosphorylation and Inactivation of Translation Initiation Factor eIF2α and Elongation Factor eEF2

Over 20000 lipid extracts of plants and marine organisms were evaluated in a human breast tumor T47D cell-based reporter assay for hypoxia-inducible factor-1 (HIF-1) inhibitory activity. Bioassay-guided isolation and dereplication-based structure elucidation of an active extract from the Bael tree (...

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Bibliografische gegevens
Hoofdauteurs: Li, Jun, Mahdi, Fakhri, Du, Lin, Datta, Sandipan, Nagle, Dale G., Zhou, Yu-Dong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179826/
https://ncbi.nlm.nih.gov/pubmed/21875114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200370z
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