Third-Generation Ah Receptor–Responsive Luciferase Reporter Plasmids: Amplification of Dioxin-Responsive Elements Dramatically Increases CALUX Bioassay Sensitivity and Responsiveness

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like chemicals are widespread and persistent environmental contaminants that produce diverse toxic and biological effects through their ability to bind to and activate the Ah receptor (AhR) and AhR-dependent gene expression. The c...

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Detalhes bibliográficos
Main Authors: He, Guochun, Tsutsumi, Tomoaki, Zhao, Bin, Baston, David S., Zhao, Jing, Heath-Pagliuso, Sharon, Denison, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
In Vitro Methods and Alternatives to Animals
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179681/
https://ncbi.nlm.nih.gov/pubmed/21775728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr189
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