Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope

The potency of DNA vaccines may be affected by the efficiency of intracellular processing and MHC class I presentation of encoded antigens. Since a single-chain trimer (SCT) composed of peptide, β2-microglobulin (β2m), and MHC class I heavy chain has been shown to bypass antigen processing and lead...

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Main Authors: Huang, C-H, Peng, S, He, L, Tsai, Y-C, Boyd, DAK, Hansen, TH, Wu, T-C, Hung, C-F
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179388/
https://ncbi.nlm.nih.gov/pubmed/15800656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3302519
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