EP1(−/−) Mice Have Enhanced Osteoblast Differentiation and Accelerated Fracture Repair

As a downstream product of cyclooxygenase 2 (COX-2), prostaglandin E(2) (PGE(2)) plays a crucial role in the regulation of bone formation. It has four different receptor subtypes (EP1 through EP4), each of which exerts different effects in bone. EP2 and EP4 induce bone formation through the protein...

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Autori principali: Zhang, Minjie, Ho, Hsin-chiu, Sheu, Tzong-jen, Breyer, Matthew D, Flick, Lisa M, Jonason, Jennifer H, Awad, Hani A, Schwarz, Edward M, O'Keefe, Regis J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179328/
https://ncbi.nlm.nih.gov/pubmed/20939055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.272
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