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In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

Recent studies have demonstrated a simple, potentially universal strategy to enhance vaccine potency, via intralymph node (i.LN) injection. To date, intranodal immunization studies have focused on the delivery of unadjuvanted vaccines (e.g., naked DNA, peptide, or protein). We hypothesized that comb...

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Библиографические подробности
Главные авторы: Jewell, Christopher M., Bustamante López, Sandra C., Irvine, Darrell J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179077/
https://ncbi.nlm.nih.gov/pubmed/21896725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105200108
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