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Myeloid-Specific Expression of Human Lysosomal Acid Lipase Corrects Malformation and Malfunction of Myeloid-derived Suppressive Cells in lal−/− Mice
Lysosomal acid lipase (LAL) cleaves cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in lysosomes. LAL deficiency causes expansion of CD11b(+)GR-1(+) immature myeloid cells, loss of T cells and impairment of T cell function. To test how myeloid cell LAL controls myel...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178672/ https://ncbi.nlm.nih.gov/pubmed/21900179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003358 |
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