Accelerated autoimmune diabetes in the absence of LAG-3

LAG-3 (CD223) is a CD4 homolog that is required for maximal regulatory T cell function and for the control of CD4(+) and CD8(+) T cell homeostasis. Lag3(−/−) NOD mice developed substantially accelerated diabetes with 100% incidence. Adoptive transfer experiments revealed that LAG-3 was primarily res...

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Main Authors: Bettini, Maria, Szymczak-Workman, Andrea L., Forbes, Karen, Castellaw, Ashley H., Selby, Mark, Pan, Xiaoyu, Drake, Charles G., Korman, Alan J., Vignali, Dario A.A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178660/
https://ncbi.nlm.nih.gov/pubmed/21873518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100714
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