Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma

Overexpression of Her2/ErbB2/Neu in cancer is often correlated with recurrent distant metastasis, although the mechanism still remains largely elusive. We have previously shown that EGFR, when tyrosine-phosphorylated, binds to GEP100/BRAG2 to activate Arf6, which induces cancer invasion and metastas...

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Autors principals: Menju, Toshi, Hashimoto, Shigeru, Hashimoto, Ari, Otsuka, Yutaro, Handa, Haruka, Ogawa, Eiji, Toda, Yoshinobu, Wada, Hiromi, Date, Hiroshi, Sabe, Hisataka
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178645/
https://ncbi.nlm.nih.gov/pubmed/21966491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025301
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