Aging Negatively Affects Estrogens-Mediated Effects on Nitric Oxide Bioavailability by Shifting ERα/ERβ Balance in Female Mice

AIMS: Aging is among the major causes for the lack of cardiovascular protection by estrogen (E2) during postmenopause. Our study aims to determine the mechanisms whereby aging changes E2 effects on nitric oxide (NO) production in a mouse model of accelerated senescence (SAM). METHODS AND RESULTS: Al...

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Main Authors: Novensà, Laura, Novella, Susana, Medina, Pascual, Segarra, Gloria, Castillo, Nadia, Heras, Magda, Hermenegildo, Carlos, Dantas, Ana Paula
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178641/
https://ncbi.nlm.nih.gov/pubmed/21966501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025335
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