Aging Negatively Affects Estrogens-Mediated Effects on Nitric Oxide Bioavailability by Shifting ERα/ERβ Balance in Female Mice

AIMS: Aging is among the major causes for the lack of cardiovascular protection by estrogen (E2) during postmenopause. Our study aims to determine the mechanisms whereby aging changes E2 effects on nitric oxide (NO) production in a mouse model of accelerated senescence (SAM). METHODS AND RESULTS: Al...

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Detalhes bibliográficos
Main Authors: Novensà, Laura, Novella, Susana, Medina, Pascual, Segarra, Gloria, Castillo, Nadia, Heras, Magda, Hermenegildo, Carlos, Dantas, Ana Paula
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178641/
https://ncbi.nlm.nih.gov/pubmed/21966501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025335
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