Towards Protein Crystallization as a Process Step in Downstream Processing of Therapeutic Antibodies: Screening and Optimization at Microbatch Scale

Crystallization conditions of an intact monoclonal IgG4 (immunoglobulin G, subclass 4) antibody were established in vapor diffusion mode by sparse matrix screening and subsequent optimization. The procedure was transferred to microbatch conditions and a phase diagram was built showing surprisingly l...

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Detaylı Bibliyografya
Asıl Yazarlar: Zang, Yuguo, Kammerer, Bernd, Eisenkolb, Maike, Lohr, Katrin, Kiefer, Hans
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178630/
https://ncbi.nlm.nih.gov/pubmed/21966480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025282
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