Differential Impact of EGFR-Targeted Therapies on Hypoxia Responses: Implications for Treatment Sensitivity in Triple-Negative Metastatic Breast Cancer

BACKGROUND: In solid tumors, such as breast cancer, cells are exposed to hypoxia. Cancer cells adapt their metabolism by activating hypoxia-inducible factors (HIFs) that promote the transcription of genes involved in processes such as cell survival, drug resistance and metastasis. HIF-1 is also indu...

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Main Authors: El Guerrab, Abderrahim, Zegrour, Rabah, Nemlin, Carine-Christiane, Vigier, Flavie, Cayre, Anne, Penault-Llorca, Frederique, Rossignol, Fabrice, Bignon, Yves-Jean
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178587/
https://ncbi.nlm.nih.gov/pubmed/21966417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025080
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