Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation

OBJECTIVE: PKC-ζ activation is a key signaling event for growth factor–induced β-cell replication in vitro. However, the effect of direct PKC-ζ activation in the β-cell in vivo is unknown. In this study, we examined the effects of PKC-ζ activation in β-cell expansion and function in vivo in mice and...

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Главные авторы: Velazquez-Garcia, Silvia, Valle, Shelley, Rosa, Taylor C., Takane, Karen K., Demirci, Cem, Alvarez-Perez, Juan C., Mellado-Gil, Jose M., Ernst, Sara, Scott, Donald K., Vasavada, Rupangi C., Alonso, Laura C., Garcia-Ocaña, Adolfo
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2011
Предметы:
Islet Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178296/
https://ncbi.nlm.nih.gov/pubmed/21911744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1783
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