Mechanisms of Control of the Free Ca(2+) Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca(2+)](c) and Role of SERCA2b and SERCA3

OBJECTIVE: Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER...

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Detalhes bibliográficos
Main Authors: Ravier, Magalie A., Daro, Dorothée, Roma, Leticia Prates, Jonas, Jean-Christophe, Cheng-Xue, Rui, Schuit, Frans C., Gilon, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178295/
https://ncbi.nlm.nih.gov/pubmed/21885870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1543
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