Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice

OBJECTIVE: Obesity, insulin resistance, and type 2 diabetes form a tightly correlated cluster of metabolic disorders in which adipose is one of the first affected tissues. The role of hypoxia and hypoxia-inducible factor 1 (HIF1) in the development of high-fat diet (HFD)–induced obesity and insulin...

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Main Authors: Jiang, Changtao, Qu, Aijuan, Matsubara, Tsutomu, Chanturiya, Tatyana, Jou, William, Gavrilova, Oksana, Shah, Yatrik M., Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178277/
https://ncbi.nlm.nih.gov/pubmed/21873554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0174
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