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Folding, Assembly, and Aggregation of Recombinant Murine Amelogenins with T21I and P41T Point Mutations

Two point mutations (T21I and P40T) within amelogenin have been identified from human DNA sequences in 2 instances of amelogenesis imperfecta. We studied the folding and self-assembly of recombinant amelogenin (rM180) compared to the T21I and P40T mutants analogs. At pH 5.8 and 25°C, rM180 and the P...

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Detalhes bibliográficos
Main Authors: Bromley, Keith M., Lakshminarayanan, Rajamani, Lei, Ya-Ping, Snead, Malcolm L., Moradian-Oldak, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178092/
https://ncbi.nlm.nih.gov/pubmed/21540557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000324342
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