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Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling
Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors. Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to switch to a differentiating cystoblast (CB). Howeve...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178012/ https://ncbi.nlm.nih.gov/pubmed/21238926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.11.019 |
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