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Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers

G protein-coupled receptors (GPCRs) transmit signals by forming active-state complexes with heterotrimeric G proteins. It has been suggested that some GPCRs also assemble with G proteins prior to ligand-induced activation, and that inactive-state preassembly facilitates rapid and specific G protein...

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Autori principali: Qin, Kou, Dong, Chunmin, Wu, Guangyu, Lambert, Nevin A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177959/
https://ncbi.nlm.nih.gov/pubmed/21873996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.642
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