Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors

With the increased use of small self-complementary adeno-associated viral (AAV) vectors, the design of compact promoters becomes critical for packaging and expressing larger transgenes under ubiquitous or cell-specific control. In a comparative study of commonly used 800-bp cytomegalovirus (CMV) and...

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Detalhes bibliográficos
Main Authors: Gray, Steven J., Foti, Stacey B., Schwartz, Joel W., Bachaboina, Lavanya, Taylor-Blake, Bonnie, Coleman, Jennifer, Ehlers, Michael D., Zylka, Mark J., McCown, Thomas J., Samulski, R. Jude
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
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Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177952/
https://ncbi.nlm.nih.gov/pubmed/21476867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.245
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