Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association

The identification of multiple signals at individual loci could explain additional phenotypic variance (‘missing heritability’) of common traits, and help identify causal genes. We examined gene expression levels as a model trait because of the large number of strong genetic effects acting in cis. U...

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Detalhes bibliográficos
Main Authors: Wood, Andrew R., Hernandez, Dena G., Nalls, Michael A., Yaghootkar, Hanieh, Gibbs, J. Raphael, Harries, Lorna W., Chong, Sean, Moore, Matthew, Weedon, Michael N., Guralnik, Jack M., Bandinelli, Stefania, Murray, Anna, Ferrucci, Luigi, Singleton, Andrew B, Melzer, David, Frayling, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177649/
https://ncbi.nlm.nih.gov/pubmed/21798870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr328
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