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Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers

Using an enhancer-associated epigenetic signature, we made genome-wide predictions of transcriptional enhancers in human B and T lymphocytes and embryonic stem cells (ES cells). We validated and characterized the predicted enhancers using four types of information, including overlap with other genom...

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Autors principals: Teng, Li, Firpi, Hiram A., Tan, Kai
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177211/
https://ncbi.nlm.nih.gov/pubmed/21685454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr476
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