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A practical, convergent route to the key precursor to the tetracycline antibiotics()
Here we describe a 5-step sequence to prepare the AB enone 1, the key precursor to fully synthetic tetracyclines, that begins with a diastereoselective Michael–Claisen coupling of two simple starting materials, a cyclohexenone (compound 2 or, in a refinement, a substituted variant, vide infra) and t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176682/ https://ncbi.nlm.nih.gov/pubmed/21949588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1SC00303H |
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