Heteroplasmic mitochondrial DNA mutations in normal and tumor cells

The presence of hundreds of copies of mitochondrial (mt) DNA in each human cell poses a challenge for complete characterization of mtDNA genomes by conventional sequencing technologies(1). Here, we describe digital sequencing of mtDNA genomes using massively parallel sequencing-by-synthesis. Though...

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Bibliografiske detaljer
Main Authors: He, Yiping, Wu, Jian, Dressman, Devin C., Iacobuzio-Donahue, Christine, Markowitz, Sanford D., Velculescu, Victor E., Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176451/
https://ncbi.nlm.nih.gov/pubmed/20200521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08802
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