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Heteroplasmic mitochondrial DNA mutations in normal and tumor cells
The presence of hundreds of copies of mitochondrial (mt) DNA in each human cell poses a challenge for complete characterization of mtDNA genomes by conventional sequencing technologies(1). Here, we describe digital sequencing of mtDNA genomes using massively parallel sequencing-by-synthesis. Though...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176451/ https://ncbi.nlm.nih.gov/pubmed/20200521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08802 |
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