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Human NK Cells Differ More in Their KIR2DL1-Dependent Thresholds for HLA-Cw6-Mediated Inhibition than in Their Maximal Killing Capacity

In this study we have addressed the question of how activation and inhibition of human NK cells is regulated by the expression level of MHC class I protein on target cells. Using target cell transfectants sorted to stably express different levels of the MHC class I protein HLA-Cw6, we show that indu...

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Bibliografische gegevens
Hoofdauteurs: Almeida, Catarina R., Ashkenazi, Amit, Shahaf, Gitit, Kaplan, Deborah, Davis, Daniel M., Mehr, Ramit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176315/
https://ncbi.nlm.nih.gov/pubmed/21949790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024927
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