HCV Causes Chronic Endoplasmic Reticulum Stress Leading to Adaptation and Interference with the Unfolded Protein Response

BACKGROUND: The endoplasmic reticulum (ER) is the cellular site for protein folding. ER stress occurs when protein folding capacity is exceeded. This stress induces a cyto-protective signaling cascades termed the unfolded protein response (UPR) aimed at restoring homeostasis. While acute ER stress i...

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Detalhes bibliográficos
Main Authors: Merquiol, Emmanuelle, Uzi, Dotan, Mueller, Tobias, Goldenberg, Daniel, Nahmias, Yaakov, Xavier, Ramnik J., Tirosh, Boaz, Shibolet, Oren
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176279/
https://ncbi.nlm.nih.gov/pubmed/21949742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024660
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