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Significant Inhibition of Corneal Scarring In Vivo with Tissue-Selective, Targeted AAV5 Decorin Gene Therapy
PURPOSE. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the stroma with adeno-associated virus serotype 5 (AAV5) inhibits corneal fibrosis in vivo without significant side effects. METHODS. An in vivo rabbit model of corneal fibrosis was used. Targete...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175954/ https://ncbi.nlm.nih.gov/pubmed/21551414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-7357 |
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