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Increased Protein Hydrophobicity in Response to Aging and Alzheimer’s disease

Increased levels of misfolded and damaged proteins occur in response to brain aging and Alzheimer’s disease (AD), which presumably increases the amount of aggregation prone proteins via elevations in hydrophobicity. The proteasome is an intracellular protease which degrades oxidized and ubiquitinate...

詳細記述

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書誌詳細
主要な著者: Dasuri, Kalavathi, Ebenezer, Philip, Zhang, Le, Fernandez-Kim, Sun Ok, Bruce-Keller, Annadora J., Markesbery, William R., Keller, Jeffrey N.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175611/
https://ncbi.nlm.nih.gov/pubmed/20188163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.02.012
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