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Increased Protein Hydrophobicity in Response to Aging and Alzheimer’s disease

Increased levels of misfolded and damaged proteins occur in response to brain aging and Alzheimer’s disease (AD), which presumably increases the amount of aggregation prone proteins via elevations in hydrophobicity. The proteasome is an intracellular protease which degrades oxidized and ubiquitinate...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Dasuri, Kalavathi, Ebenezer, Philip, Zhang, Le, Fernandez-Kim, Sun Ok, Bruce-Keller, Annadora J., Markesbery, William R., Keller, Jeffrey N.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175611/
https://ncbi.nlm.nih.gov/pubmed/20188163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.02.012
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