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Increased Protein Hydrophobicity in Response to Aging and Alzheimer’s disease

Increased levels of misfolded and damaged proteins occur in response to brain aging and Alzheimer’s disease (AD), which presumably increases the amount of aggregation prone proteins via elevations in hydrophobicity. The proteasome is an intracellular protease which degrades oxidized and ubiquitinate...

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Detalles Bibliográficos
Main Authors: Dasuri, Kalavathi, Ebenezer, Philip, Zhang, Le, Fernandez-Kim, Sun Ok, Bruce-Keller, Annadora J., Markesbery, William R., Keller, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175611/
https://ncbi.nlm.nih.gov/pubmed/20188163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.02.012
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