A mechanism-based model for the population pharmacokinetics of free and bound aflibercept in healthy subjects

AIM: Aflibercept (VEGF-Trap), a novel anti-angiogenic agent that binds to VEGF, has been investigated for the treatment of cancer. The aim of this study was to develop a mechanism-based pharmacokinetic (PK) model for aflibercept to characterize its binding to VEGF and its PK properties in healthy su...

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Detalles Bibliográficos
Main Authors: Thai, Hoai-Thu, Veyrat-Follet, Christine, Vivier, Nicole, Dubruc, Catherine, Sanderink, Gerard, Mentré, France, Comets, Emmanuelle
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2011
Assuntos:
Pharmacokinetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175510/
https://ncbi.nlm.nih.gov/pubmed/21575034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04015.x
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