Synthesis and Characterization of Conformationally-Preorganized, MiniPEG-Containing γPNAs with Superior Hybridization Properties and Water Solubility

Developed in the early 1990's, PNA has emerged as a promising class of nucleic acid mimic because of its strong binding affinity and sequence selectivity towards DNA and RNA, and resistance to enzymatic degradation by proteases and nucleases; however, the main drawbacks, as compared to other cl...

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Main Authors: Sahu, Bichismita, Sacui, Iulia, Rapireddy, Srinivas, Zanotti, Kimberly J., Bahal, Raman, Armitage, Bruce A., Ly, Danith H.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175361/
https://ncbi.nlm.nih.gov/pubmed/21619025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo200482d
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