Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

To identify regulators of intracellular signaling we targeted 541 kinases and kinase-related molecules with siRNAs and determined their effects on signaling with a functional proteomics reverse phase protein array (RPPA) platform assessing 42 phospho and total proteins. The kinome wide screen demons...

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Bibliografiske detaljer
Main Authors: Lu, Yiling, Muller, Melissa, Smith, Debra, Dutta, Bhaskar, Komurov, Kakajan, Iadevaia, Sergio, Ruths, Derek, Tseng, Jen-Te, Yu, Shuangxing, Yu, Qinghua, Nakhleh, Luay, Balazsi, Gabor, Donnelly, Jennifer, Schurdak, Mark, Morgan-Lappe, Susan, Fesik, Stephen, Ram, Prahlad T., Mills, Gordon B.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175328/
https://ncbi.nlm.nih.gov/pubmed/21666717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.164
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