Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats

BACKGROUND: Cognitive impairment has been reported in human immune deficiency virus-1- (HIV-1-) infected patients as well as in HIV-1 transgenic (Tg) rats. This impairment has been linked to neuroinflammation, disturbed brain arachidonic acid (AA) metabolism, and synapto-dendritic injury. We recentl...

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Hauptverfasser: Rao, Jagadeesh Sridhara, Kim, Hyung-Wook, Kellom, Matthew, Greenstein, Dede, Chen, Mei, Kraft, Andrew David, Harry, Gaylia Jean, Rapoport, Stanley Isaac, Basselin, Mireille
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175175/
https://ncbi.nlm.nih.gov/pubmed/21846384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-101
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