Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms

Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we analyzed the mode of action of PIM anti-inflammatory effects. Synthetic PIM(1)...

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Hauptverfasser: Court, Nathalie, Rose, Stéphanie, Bourigault, Marie-Laure, Front, Sophie, Martin, Olivier R., Dowling, Jennifer K., Kenny, Elaine F., O'Neill, Luke, Erard, François, Quesniaux, Valerie F. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174970/
https://ncbi.nlm.nih.gov/pubmed/21949737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024631
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