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Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria
The de novo and salvage dTTP pathways are essential for maintaining cellular dTTP pools to ensure the faithful replication of both mitochondrial and nuclear DNA. Disregulation of dTTP pools results in mitochondrial dysfunction and nuclear genome instability due to an increase in uracil misincorporat...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174652/ https://ncbi.nlm.nih.gov/pubmed/21876188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103623108 |
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