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Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury

While mitogen-activated protein kinase (MAPK) activation has been implicated in the pathogenesis of various glomerular diseases, including nephrotic syndrome (NS), its specific role in podocyte injury is not known. We hypothesized that MK-2, a downstream substrate of p38 MAPK, mediates the adverse e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pengal, Ruma, Guess, Adam J., Agrawal, Shipra, Manley, Joshua, Ransom, Richard F., Mourey, Robert J., Benndorf, Rainer, Smoyer, William E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174552/
https://ncbi.nlm.nih.gov/pubmed/21613416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00661.2010
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