Activation of the Wnt/β-Catenin Signaling Pathway by Mechanical Ventilation Is Associated with Ventilator-Induced Pulmonary Fibrosis in Healthy Lungs

BACKGROUND: Mechanical ventilation (MV) with high tidal volumes (V(T)) can cause or aggravate lung damage, so-called ventilator induced lung injury (VILI). The relationship between specific mechanical events in the lung and the cellular responses that result in VILI remains incomplete. Since activat...

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Autori principali: Villar, Jesús, Cabrera, Nuria E., Valladares, Francisco, Casula, Milena, Flores, Carlos, Blanch, Lluís, Quilez, María Elisa, Santana-Rodríguez, Norberto, Kacmarek, Robert M., Slutsky, Arthur S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174135/
https://ncbi.nlm.nih.gov/pubmed/21935365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023914
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